Association of cortical thickness and cognition with schizophrenia treatment resistance.

ABSTRACT:

Aim

Approximately a third of patients with schizophrenia fail to adequately respond to antipsychotic medications, a condition known as treatment resistance (TR). We aimed to assess cognitive and cortical thickness deficits and their relationship to TR in schizophrenia.

Method

We recruited patients with schizophrenia (n = 127), including patients at treatment initiation (n = 45), treatment-responsive patients (n = 40) and TR patients (n = 42), and healthy controls (n = 83). Clinical symptoms, neurocognitive function, and structural images were assessed. We performed group comparisons, and explored association of cortical thickness and cognition with TR.

Results

The TR patients showed significantly more severe clinical symptoms and cognitive impairment relative to the t

SUBMITTER: Fan F 

PROVIDER: S-EPMC9812867 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature