The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces.

ABSTRACT: Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their cognate natural products. To exploit their full biosynthetic potential, better understanding of the signals that promote the expression of BGCs is needed. Here, we show that the human stress hormone epinephrine (adrenaline) elicits siderophore production by Actinobacteria. Catechol was established as the likely eliciting moiety, since similar responses were seen for catechol and for the catechol-containing molecules dopamine and catechin but not for related molecules. Exploration of the catechol-

SUBMITTER: van Bergeijk DA 

PROVIDER: S-EPMC9814775 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature