First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours.

ABSTRACT:

Purpose

[¹¹C]Metomidate positron emission tomography (PET) is currently used for staging of adrenocortical carcinoma and for lateralization in primary aldosteronism (PA). Due to the short half-life of carbon-11 and a high non-specific liver uptake of [¹¹C]metomidate there is a need for improved adrenal imaging methods. In a previous pre-clinical study para-chloro-2-[¹⁸F]fluoroethyletomidate has been proven to be a specific adrenal tracer. The objective is to perform a first evaluation of para-chloro-2-[¹⁸F]fluoroethyletomidate positron emission computed tomography ([¹⁸F]CETO-PET/CT) in patients with adrenal tumours and healthy volunteers.

Methods

Fifteen patients underwent [¹⁸F]CETO-PET/CT. Five healthy volunt

SUBMITTER: Silins I 

PROVIDER: S-EPMC9816205 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature