MRI/PAI Dual-modal Imaging-guided Precise Tracking of Bone Marrow-derived Mesenchymal Stem Cells Labeled with Nanoparticles for Treating Liver Cirrhosis.

ABSTRACT:

Background and aims

Stem cell transplantation is a potential treatment option for liver cirrhosis (LC). Accurately and noninvasively monitoring the distribution, migration, and prognosis of transplanted stem cells using imaging methods is important for in-depth study of the treatment mechanisms. Our study aimed to develop Au-Fe₃O₄ silica nanoparticles (NPs) as tracking nanoplatforms for dual-modal stem cell imaging.

Methods

Au-Fe₃O₄ silica NPs were synthesized by seed-mediated growth method and co-precipitation. The efficiency and cytotoxicity of the NPs-labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) were evaluated by Cell Counting Kit-8 assays, ICP-MS, phenotypic characterization, and histological staining. The biodi

SUBMITTER: Liu FY 

PROVIDER: S-EPMC9817052 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature