Gene Expression Profiles of the Immuno-Transcriptome in Equine Asthma.

ABSTRACT:

Background

Mild equine asthma (MEA) and severe equine asthma (SEA) are two of the most frequent equine airway inflammatory diseases, but knowledge about their pathogenesis is limited. The goal of this study was to investigate gene expression differences in the respiratory tract of MEA- and SEA-affected horses and their relationship with clinical signs.

Methods

Clinical examination and endoscopy were performed in 8 SEA- and 10 MEA-affected horses and 7 healthy controls. Cytological and microbiological analyses of bronchoalveolar lavage (BAL) fluid were performed. Gene expression profiling of BAL fluid was performed by means of a custom oligo-DNA microarray.

Results

In both MEA and SEA, genes involved in the genesis, length, and motility of respiratory epithelium cilia

SUBMITTER: Padoan E 

PROVIDER: S-EPMC9817691 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature