The γ-Core Motif Peptides of Plant AMPs as Novel Antimicrobials for Medicine and Agriculture.

ABSTRACT: The γ-core motif is a structural element shared by most host antimicrobial peptides (AMPs), which is supposed to contribute to their antimicrobial properties. In this review, we summarized the available data on the γ-core peptides of plant AMPs. We describe γ-core peptides that have been shown to exhibit inhibitory activity against plant and human bacterial and fungal pathogens that make them attractive scaffolds for the development of novel anti-infective agents. Their advantages include origin from natural AMP sequences, broad-spectrum and potent inhibitory activity, and cost-effective production. In addition, some γ-core peptides combine antimicrobial and immunomodulatory functions, thus broadening the spectrum of practical applications. Some act synergistically with antimycotics and fu

SUBMITTER: Slezina MP 

PROVIDER: S-EPMC9820530 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature