Ontology highlight
ABSTRACT:
SUBMITTER: Eshima J
PROVIDER: S-EPMC9822908 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Eshima Jarrett J O'Connor Samantha A SA Marschall Ethan E Bowser Robert R Plaisier Christopher L CL Smith Barbara S BS
Nature communications 20230106 1
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood clinical heterogeneity, underscored by significant differences in patient age at onset, symptom progression, therapeutic response, disease duration, and comorbidity presentation. We perform a patient stratification analysis to better understand the variability in ALS pathology, utilizing postmortem frontal and motor cortex transcriptomes derived from 208 patients. Building on the emerging role of transposab ...[more]