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Direct Synthesis of 3-Aryl Substituted Isocoumarins and Phthalides through Palladium Acetate Catalyzed C(sp² )-H Activation in Ionic Liquids.

ABSTRACT: A novel Pd-catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C-H bond activation, with very low percentage of ligand-free palladium acetate as the catalyst, under atmospheric pressure of oxygen. Sub-stoichiometric amount of copper acetate is also required as a reoxidant for the palladium.

SUBMITTER: Aloia A

PROVIDER: S-EPMC9826210 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Direct Synthesis of 3-Aryl Substituted Isocoumarins and Phthalides through Palladium Acetate Catalyzed C(sp2 )-H Activation in Ionic Liquids.

Aloia Andrea A Casiello Michele M D'Accolti Lucia L Fusco Caterina C Nacci Angelo A Monopoli Antonio A

Chemistry (Weinheim an der Bergstrasse, Germany) 20220919 65

A novel Pd-catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C-H bond activation, with very low percentage of ligand-free palladium acetate as the catalyst, under atmospheric pressure of oxygen. Sub-stoichiometric amount of copper acetate is also required as a reoxidant for the palladium. ...[more]

PMID: 35997238

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