MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer.

ABSTRACT: Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men worldwide. Despite the presence of accumulated clinical strategies for PCa management, limited prognostic/sensitive biomarkers are available to follow up on disease occurrence and progression. MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression through post-transcriptional regulation of their complementary target messenger RNA (mRNA). MiRNAs modulate fundamental biological processes and play crucial roles in the pathology of various diseases, including PCa. Multiple evidence proved an aberrant miRNA expression profile in PCa, which is actively involved in the carcinogenic process. The robust and pleiotropic impact of miRNAs on PCa suggests them as potential candidates to help more understand

SUBMITTER: Ghamlouche F 

PROVIDER: S-EPMC9827391 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature