The in-hospital tuberculosis diagnostic cascade and early clinical outcomes among people living with HIV before and during the COVID-19 pandemic - a prospective multisite cohort study from Ghana.

ABSTRACT:

Objectives

The COVID-19 pandemic had a disruptive impact on tuberculosis (TB) and HIV services. We assessed the in-hospital TB diagnostic care among people with HIV (PWH) overall and before and during the pandemic.

Methods

In this prospective study, adult PWH admitted at three hospitals in Ghana were recruited if they had a positive World Health Organization four-symptom screen or one or more World Health Organization danger signs or advanced HIV. We collected data on patient characteristics, TB assessment, and clinical outcomes after 8 weeks and used descriptive statistics and survival analysis.

Results

We enrolled 248 PWH with a median clusters of differentiation 4 count of 80.5 cells/mm³ (interquartile range 24-193). Of those, 246 (99.2%) patients had a

SUBMITTER: Ahsberg J 

PROVIDER: S-EPMC9827749 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature