Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females.

ABSTRACT:

Background

Social experiences influence susceptibility to substance use disorder. The adolescent period is associated with the development of social reward and is exceptionally sensitive to disruptions to reward-associated behaviors by social experiences. Social isolation (SI) during adolescence alters anxiety- and reward-related behaviors in adult males, but little is known about females. The medial amygdala (meA) is a likely candidate for the modulation of social influence on drug reward because it regulates social reward, develops during adolescence, and is sensitive to social stress. However, little is known regarding how the meA responds to drugs of abuse.

Methods

We used adolescent SI coupled with RNA sequencing to better understand the molecular mechanisms underlying

SUBMITTER: Walker DM 

PROVIDER: S-EPMC9828478 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature