Pre-Existing Autoimmune Disease Increases the Risk of Cardiovascular and Noncardiovascular Events After Immunotherapy.

ABSTRACT:

Background

The use of immune checkpoint inhibitors (ICI) is associated with cardiovascular (CV) events, and patients with pre-existing autoimmune disease are at increased CV risk.

Objectives

The aim of this study was to characterize the risk for CV events in patients with pre-existing autoimmune disease post-ICI.

Methods

This was a retrospective study of 6,683 patients treated with ICIs within an academic network. Autoimmune disease prior to ICI was confirmed by chart review. Baseline characteristics and risk for CV and non-CV immune-related adverse events were compared with a matched control group (1:1 ratio) of ICI patients without autoimmune disease. Matching was based on age, sex, history of coronary artery disease, history of heart failure, and diabetes mellitus.

SUBMITTER: Lee C 

PROVIDER: S-EPMC9830202 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature