Dataset Information

Factors associated with selection of targeted therapy in patients with rheumatoid arthritis.

ABSTRACT:

Objective

Deciding which drug to choose for targeted therapy is an important step in sequential treatment for rheumatoid arthritis (RA). This study aimed to identify factors for selecting Janus kinase inhibitors (JAKis) rather than biologic disease-modifying antirheumatic drugs (bDMARDs) in patients with RA in real-world practice.

Methods

We selected RA patients starting JAKis or bDMARDs from single-center prospective cohorts in Korea. Patients were divided into JAKi, tumor necrosis factor (TNF) inhibitor, and non-TNF inhibitor groups. We performed multinomial logistic regression analyses to identify factors associated with selecting JAKis.

Results

145, 205, and 89 patients were included in the JAKi, TNF inhibitor, and non-TNF inhibitor groups. In multinomial regression analysis, the JAKi group was older than the TNF inhibitor group (OR 1.03, 95% confidence interval [CI] 1.01-1.05) but younger than the non-TNF inhibitor group (OR 0.97, CI 0.95-1.00). The JAKi group was less likely to have chronic pulmonary diseases compared with the TNF inhibitor group (OR 0.07, CI 0.01-0.56) or the non-TNF inhibitor group (OR 0.06, CI 0.01-0.50). Higher disease activity assessed by physician (OR 1.80, CI 1.51-2.38) and previous tacrolimus use (OR 2.05, CI 1.20-3.51) were factors suggesting selection of JAKis than TNF inhibitors.

Conclusion

Age, pulmonary comorbidities, previous tacrolimus use, and high disease activity assessed by physician were factors influencing the selection of JAKis for RA patients in Korea.

SUBMITTER: Song YJ

PROVIDER: S-EPMC9831325 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Factors associated with selection of targeted therapy in patients with rheumatoid arthritis.

Song Yeo-Jin YJ Cho Soo-Kyung SK Kim Hyoungyoung H Kim Hye Won HW Nam Eunwoo E Choi Chan-Bum CB Kim Tae-Hwan TH Jun Jae-Bum JB Bae Sang-Cheol SC Yoo Dae Hyun DH Sung Yoon Kyoung YK

PloS one 20230110 1

<h4>Objective</h4>Deciding which drug to choose for targeted therapy is an important step in sequential treatment for rheumatoid arthritis (RA). This study aimed to identify factors for selecting Janus kinase inhibitors (JAKis) rather than biologic disease-modifying antirheumatic drugs (bDMARDs) in patients with RA in real-world practice.<h4>Methods</h4>We selected RA patients starting JAKis or bDMARDs from single-center prospective cohorts in Korea. Patients were divided into JAKi, tumor necros ...[more]

PMID: 36626396

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Dataset Information

Factors associated with selection of targeted therapy in patients with rheumatoid arthritis.

Objective

Methods

Results

Conclusion

Publications

Factors associated with selection of targeted therapy in patients with rheumatoid arthritis.

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