A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination.

ABSTRACT:

Objective

Lateral flow assays (LFA) are sensitive for detecting antibodies to SARS-CoV-2 proteins within weeks after infection. This study tested samples from immunocompetent adults, and those receiving treatments for chronic inflammatory diseases (CID), before and after mRNA SARS-CoV-2 vaccination.

Methods

We compared results obtained with the COVIBLOCK Covid-19 LFA to those obtained by anti-spike (S) ELISA.

Results

The LFA detected anti-S antibodies in 29 of 29 (100%) of the immunocompetent and 110 of 126 (87.3%) of the CID participants after vaccination. Semiquantitative LFA scores were statistically significantly lower in samples from immunosuppressed participants, and were significantly correlated with anti-S antibody levels measured by ELISA.

Conclusions

SUBMITTER: Greene SE 

PROVIDER: S-EPMC9831968 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature