Oxytocin-Receptor Gene Modulates Reward-Network Connection and Relationship with Empathy Performance.

ABSTRACT:

Introduction

Empathy traits are highly heritable and linked with reward processing. It is implicated that common variations of the oxytocin-receptor gene (OXTR) play a modulatory effect on empathic performance. However, it is unclear about the neural substrates underlying the modulatory effect of the OXTR genotype on empathic performance. This study aimed to characterize the modulatory effect of common OXTR variations on reward-circuitry function and its relationship with empathy.

Methods

Based on the seed of the nucleus accumbens (NAcc; a key hub of reward circuitry), we examined differences in spontaneous local activity and functional connectivity between OXTR rs2268493 genotype groups and their relationship with empathic performance among 402 h

SUBMITTER: Li D 

PROVIDER: S-EPMC9833327 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature