Dataset Information
MiR-100 rs1834306 A>G Increases Biliary Atresia Risk in Southern Han Chinese Children.
Ontology highlight
ABSTRACT: Background
Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. miR-100 plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in miR-100 has been proven to modulate susceptibility to various diseases.Methods
We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects.Results
Our results showed that rs1834306 A>G was correlated with a significantly increased risk for BA (GG vs. AA: adjusted odds ratio (OR) = 1.44, 95%confidence interval (CI) = 1.02-2.03, p = 0.041; and GG vs. AA/AG: adjusted OR = 1.39, 95%CI = 1.02-1.89, p = 0.036).Conclusions
Our results showed that the rs1834306 A>G polymorphism is associated with an increased risk for BA and contributes to BA susceptibility.
SUBMITTER: Chang J
PROVIDER: S-EPMC9833893 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
<i>MiR-100</i> rs1834306 A>G Increases Biliary Atresia Risk in Southern Han Chinese Children.
BioMed research international 20230104
<h4>Background</h4>Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. <i>miR-100</i> plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in <i>miR-100</i> has been proven to modulate susceptibility to various diseases.<h4>Methods</h4>We conducted a case-control retrospective study to explore the correlation between <i>miR-100</i> gene polymorphism (rs1834306 A>G) and bili ...[more]
