Dataset Information

Simultaneous assessment of myocardial perfusion and adrenergic innervation in patients with heart failure by low-dose dual-isotope CZT SPECT imaging.

ABSTRACT:

Background

In patients with heart failure (HF) sequential imaging studies have demonstrated a relationship between myocardial perfusion and adrenergic innervation. We evaluated the feasibility of a simultaneous low-dose dual-isotope ¹²³I/^99mTc-acquisition protocol using a cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) camera.

Methods and results

Thirty-six patients with HF underwent simultaneous low-dose ¹²³I-metaiodobenzylguanidine (MIBG)/^99mTc-sestamibi gated CZT-SPECT cardiac imaging. Perfusion and innervation total defect sizes and perfusion/innervation mismatch size (defined by ¹²³I-MIBG defect size minus ^99mTc-sestamibi defect size) were expressed as percentages of the total left ventricular (LV) surface area. LV ejection fraction (EF) significantly correlated with perfusion defect size (P < .005), innervation defect size (P < .005), and early (P < .05) and late (P < .01) ¹²³I-MIBG heart-to-mediastinum (H/M) ratio. In addition, late H/M ratio was independently associated with reduced LVEF (P < .05). Although there was a significant relationship (P < .001) between perfusion and innervation defect size, innervation defect size was larger than perfusion defect size (P < .001). At multivariable linear regression analysis, ¹²³I-MIBG washout rate (WR) correlated with perfusion/innervation mismatch (P < .05).

Conclusions

In patients with HF, a simultaneous low-dose dual-isotope ¹²³I/^99mTc-acquisition protocol is feasible and could have important clinical implications.

SUBMITTER: Assante R

PROVIDER: S-EPMC9834348 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Simultaneous assessment of myocardial perfusion and adrenergic innervation in patients with heart failure by low-dose dual-isotope CZT SPECT imaging.

Assante Roberta R D'Antonio Adriana A Mannarino Teresa T Nappi Carmela C Gaudieri Valeria V Zampella Emilia E Buongiorno Pietro P Cantoni Valeria V Green Roberta R Frega Nicola N Verberne Hein J HJ Petretta Mario M Cuocolo Alberto A Acampa Wanda W

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20220404 6

<h4>Background</h4>In patients with heart failure (HF) sequential imaging studies have demonstrated a relationship between myocardial perfusion and adrenergic innervation. We evaluated the feasibility of a simultaneous low-dose dual-isotope <sup>123</sup>I/<sup>99m</sup>Tc-acquisition protocol using a cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) camera.<h4>Methods and results</h4>Thirty-six patients with HF underwent simultaneous low-dose <sup>123</sup>I-metaio ...[more]

PMID: 35378694

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Dataset Information

Simultaneous assessment of myocardial perfusion and adrenergic innervation in patients with heart failure by low-dose dual-isotope CZT SPECT imaging.

Background

Methods and results

Conclusions

Publications

Simultaneous assessment of myocardial perfusion and adrenergic innervation in patients with heart failure by low-dose dual-isotope CZT SPECT imaging.

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