Molecular imaging of HER2 expression in breast cancer patients using a novel peptide-based tracer ^99mTc-HP-Ark2: a pilot study.

ABSTRACT:

Background

Due to the temporal and spatial heterogeneity of human epidermal growth factor receptor 2 (HER2) expression in breast tumors, immunohistochemistry (IHC) cannot accurately reflect the HER2 status in real time, which may cause misguided treatment decisions. HER2-specific imaging can noninvasively determine HER2 status in primary and metastatic tumors. In this study, HER2 expression in breast cancer patients was determined in vivo by SPECT/CT of ^99mTc-HP-Ark2, comparing with PET/CT of ¹⁸F-FDG lesion by lesion.

Methods

A novel HER2-targeted peptide probe ^99mTc-HP-Ark2 was constructed. Biodistribution and nanoScan SPECT/CT imaging were performed in mice models. The correlation between the quantified tumor uptake and HER2 expression in t

SUBMITTER: Shi J 

PROVIDER: S-EPMC9835228 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature