Improved bias and reproducibility of coronary artery calcification features using deconvolution.

ABSTRACT:

Purpose

Our long-range goal is to improve whole-heart CT calcium scores by extracting quantitative features from individual calcifications. Here, we perform deconvolution to improve bias/reproducibility of small calcification assessments, which can be degraded at the normal CT calcium score image resolution.

Approach

We analyzed features of individual calcifications on repeated standard (2.5 mm) and thin (1.25 mm) slice scans from QRM-Cardio phantom, cadaver hearts, and CARDIA study participants. Preprocessing to improve the resolution involved of Lucy-Richardson deconvolution with a measured point spread function (PSF) or three-dimensional blind deconvolution in which the PSF was iteratively optimized on high detail structures such as calcifications in images.

Results

SUBMITTER: Song Y 

PROVIDER: S-EPMC9836910 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature