Association between intraoperative tidal volume and postoperative respiratory complications is dependent on respiratory elastance: a retrospective, multicentre cohort study.

ABSTRACT:

Background

The impact of high vs low intraoperative tidal volumes on postoperative respiratory complications remains unclear. We hypothesised that the effect of intraoperative tidal volume on postoperative respiratory complications is dependent on respiratory system elastance.

Methods

We retrospectively recorded tidal volume (Vt; ml kg^-1 ideal body weight [IBW]) in patients undergoing elective, non-cardiothoracic surgery from hospital registry data. The primary outcome was respiratory failure (requiring reintubation within 7 days of surgery, desaturation after extubation, or both). The primary exposure was defined as the interaction between Vt and standardised respiratory system elastance (driving pressure divided by Vt; cm H₂O/[ml kg^-1]). Mu

SUBMITTER: Suleiman A 

PROVIDER: S-EPMC9837741 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature