The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling.

ABSTRACT: The Severe Acute Respiratory Syndrome Coronavirus 2 (CoV-2) pandemic has affected millions globally. A significant complication of CoV-2 infection is secondary bacterial co-infection, as seen in approximately 25% of severe cases. The most common organism isolated during co-infection is Staphylococcus aureus. Here, we describe the development of an in vitro co-infection model where both viral and bacterial replication kinetics may be examined. We demonstrate CoV-2 infection does not alter bacterial interactions with host epithelial cells. In contrast, S. aureus enhances CoV-2 replication by 10- to 15-fold. We identify this pro-viral activity is due to the S. aureus iron-regulated surface determinant A (IsdA) protein and demonstrate IsdA modifies host transcriptio

SUBMITTER: Goncheva MI 

PROVIDER: S-EPMC9838083 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature