Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration.

ABSTRACT:

Background

Pathological choroidal neovascularization (CNV) is one of the major causes of visual impairment in neovascular age-related macular degeneration (AMD). CNV has been suppressed by using anti-vascular endothelial growth factor (VEGF) antibodies. However, some clinical cases have demonstrated the failure of anti-VEGF therapies. Furthermore, anti-VEGF agents might induce the development of ocular atrophy. Recently, peroxisome proliferator-activated receptor alpha (PPARα) activation using pemafibrate treatment was suggested as one of the promising therapeutic targets in the prevention of ocular ischemia. However, the preventive role of pemafibrate remains unclear in CNV. We aimed to examine the preventive role of pemafibrate on laser-induced pathological CNV.

Methods

SUBMITTER: Lee D 

PROVIDER: S-EPMC9838199 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature