Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.

ABSTRACT:

Introduction

Maternal body composition may influence fetal body composition.

Objective

The objective of this pilot study was to investigate the relationship between maternal and fetal body composition.

Methods

Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation.

Results

Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2 [4.2, 5.5]% vs. 3.2 [3, 3.3]% vs. 1.9 [1.4, 3.7]%, p = 0.004). Fetal hepati

SUBMITTER: Strobel KM 

PROVIDER: S-EPMC9840659 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature