Impact of Evolutionary Changes in Nonalcoholic Fatty Liver Disease on Lung Function Decline.

ABSTRACT:

Background/aims

A relationship between fatty liver and lung function impairment has been identified, and both are independently associated with metabolic dysfunction. However, the temporal relationship between changes in fatty liver status and lung function and their genome-wide association remain unclear.

Methods

This longitudinal cohort consisted of subjects who received serial health check-ups, including liver ultrasonography and spirometry, for ≥3 years between 2003 and 2015. Lung function decline rates were classified as "slow" and "accelerated" and compared among four different sonographic changes in steatosis status: "normal," "improved," "worsened," and "persistent." A genome-wide association study was conducted between the two groups: normal/improved steatosis with

SUBMITTER: Lee HW 

PROVIDER: S-EPMC9840916 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature