LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

ABSTRACT:

Background

The therapeutic value of targeted therapies in patients with lung cancer is reduced when tumours acquire secondary resistance after an initial period of successful treatment. However, the molecular events behind the resistance to targeted therapies in lung cancer remain largely unknown.

Aims

To discover the important role and mechanism of lncRNA BC in promoting tumor metastasis and influencing clinical prognosis of LUAD.

Materials & methods

Microarrays were used to screen a comprehensive set of lncRNAs with differential expression profiles in lung cancer cells. The functional role and mechanism of lncRNA were further investigated by gain- and loss-of-function assays. RNA pull-down, protein assays, and mass spectrometry were used to identify proteins that in

SUBMITTER: Chen QW 

PROVIDER: S-EPMC9845120 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature