Interplay between C1-inhibitor and group IIA secreted phospholipase A₂ impairs their respective function.

ABSTRACT: High levels of human group IIA secreted phospholipase A₂ (hGIIA) have been associated with various inflammatory disease conditions. We have recently shown that hGIIA activity and concentration are increased in the plasma of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and negatively correlate with C1-INH plasma activity. In this study, we analyzed whether the presence of both hGIIA and C1-INH impairs their respective function on immune cells. hGIIA, but not recombinant and plasma-derived C1-INH, stimulates the production of IL-6, CXCL8, and TNF-α from peripheral blood mononuclear cells (PBMCs). PBMC activation mediated by hGIIA is blocked by RO032107A, a specific hGIIA inhibitor. Interestingly, C1-INH inhibits the hGIIA-induced production of IL

SUBMITTER: Ferrara AL 

PROVIDER: S-EPMC9845149 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature