Separable mechanisms drive local and global polarity establishment in the Caenorhabditiselegans intestinal epithelium.

ABSTRACT: Apico-basolateral polarization is essential for epithelial cells to function as selective barriers and transporters, and to provide mechanical resilience to organs. Epithelial polarity is established locally, within individual cells to establish distinct apical, junctional and basolateral domains, and globally, within a tissue where cells coordinately orient their apico-basolateral axes. Using live imaging of endogenously tagged proteins and tissue-specific protein depletion in the Caenorhabditiselegans embryonic intestine, we found that local and global polarity establishment are temporally and genetically separable. Local polarity is initiated prior to global polarity and is robust to perturbation. PAR-3 is required for global polarization across the intestine but local polarity can aris

SUBMITTER: Pickett MA 

PROVIDER: S-EPMC9845746 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature