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A DNA-engineered metal–organic-framework nanocarrier as a general platform for activatable photodynamic cancer cell ablation† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2na00509c

ABSTRACT: Activatable photodynamic cancer cell ablation constitutes a promising approach to performing highly effective photodynamic therapy (PDT) with mitigated phototoxicity. Regretfully, so far strategies to fabricate activatable PDT agents are only applicable to a limited number of photosensitizers (PSs). Herein, an activatable photodynamic cancer cell ablation platform that can be adopted for versatile PSs is presented. Thereinto, by engineering an iron(iii) carboxylate-based metal–organic framework (MOF), MIL-101(Fe), with DNA grafted after PS loading, both hydrophilic and hydrophobic PSs can undergo negligible unspecific leakage and significant suppression of photosensitization during delivery. Following the reaction between MIL-101 and H2O2 whose level is greatly increased inside the tumor, MIL-101 is selectively degraded to release the loaded PDT agents and recover their photosensitization, controllably killing cancer cells upon H2O2 activation. Such a strategy assisted by a DNA-functionalized MOF significantly expands the varieties of PSs applicable for activatable PDT. A DNA-engineered metal–organic-framework nanocarrier is proven to be a general platform for both hydrophobic and hydrophilic photosensitizers to realize activatable photodynamic cancer cell ablation.

SUBMITTER: Ma Y

PROVIDER: S-EPMC9846515 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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