A DNA-engineered metal-organic-framework nanocarrier as a general platform for activatable photodynamic cancer cell ablation.

ABSTRACT: Activatable photodynamic cancer cell ablation constitutes a promising approach to performing highly effective photodynamic therapy (PDT) with mitigated phototoxicity. Regretfully, so far strategies to fabricate activatable PDT agents are only applicable to a limited number of photosensitizers (PSs). Herein, an activatable photodynamic cancer cell ablation platform that can be adopted for versatile PSs is presented. Thereinto, by engineering an iron(iii) carboxylate-based metal-organic framework (MOF), MIL-101(Fe), with DNA grafted after PS loading, both hydrophilic and hydrophobic PSs can undergo negligible unspecific leakage and significant suppression of photosensitization during delivery. Following the reaction between MIL-101 and H₂O₂ whose level is greatly increa

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9846515 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature