Urocortin-3 neurons in the perifornical area are critical mediators of chronic stress on female infant-directed behavior.

ABSTRACT: Infant avoidance and aggression are promoted by activation of the Urocortin-3 expressing neurons of the perifornical area of hypothalamus (PeFA^Ucn3) in male and female mice. PeFA^Ucn3 neurons have been implicated in stress, and stress is known to reduce maternal behavior. We asked how chronic restraint stress (CRS) affects infant-directed behavior in virgin and lactating females and what role PeFA^Ucn3 neurons play in this process. Here we show that infant-directed behavior increases activity in the PeFA^Ucn3 neurons in virgin and lactating females. Chemogenetic inhibition of PeFA^Ucn3 neurons facilitates pup retrieval in virgin females. CRS reduces pup retrieval in virgin females and increases activity of PeFA^Ucn3 neurons, whil

SUBMITTER: Abdelmesih B 

PROVIDER: S-EPMC9847478 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature