An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery.

ABSTRACT: Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages for patient-comfort when deploying epidermal diseases treatments. However, current self-powered iontophoresis based on energy harvesters is limited to support efficient therapeutic administration over the long-term operation, owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug reservoir and cathode material, eliminating the conventional interface impedance between the electrode and drug reservoir. The redox-active polyelectrolyte hydrogel offe

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9849227 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature