Parallel learning and cognitive flexibility impairments between Fmr1 knockout mice and individuals with fragile X syndrome.

ABSTRACT:

Introduction

Fragile X Syndrome (FXS) is a monogenic condition that leads to intellectual disability along with behavioral and learning difficulties. Among behavioral and learning difficulties, cognitive flexibility impairments are among the most commonly reported in FXS, which significantly impacts daily living. Despite the extensive use of the Fmr1 knockout (KO) mouse to understand molecular, synaptic and behavioral alterations related to FXS, there has been limited development of translational paradigms to understand cognitive flexibility that can be employed in both animal models and individuals with FXS to facilitate treatment development.

Methods

To begin addressing this limitation, a parallel set of studies were carried out that investigated probabilistic rever

SUBMITTER: Schmitt LM 

PROVIDER: S-EPMC9849779 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature