Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells.

ABSTRACT: Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive (ApoB⁺) CD4 T cells are mostly regulatory T cells (T_regs), which exert anti-inflammatory effects. Yet, they may obtain pro-inflammatory features and thus become proatherogenic. Evidence from animal studies suggests that vaccination against certain major histocompatibility complex (MHC) II-binding ApoB peptides induces an expansion of ApoB⁺ T_regs and thus confers atheroprotection. To date, in-depth phenotyping of vaccine-expanded ApoB⁺ T cells has not yet been performed. To this e

SUBMITTER: Nettersheim FS 

PROVIDER: S-EPMC9849899 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature