Vascular alterations impede fragile tolerance to pregnancy in type 1 diabetes.

ABSTRACT:

Objective

To determine the impact of autoimmunity in the absence of glycemic alterations on pregnancy in type 1 diabetes (T1D).

Design

Because nonobese diabetic (NOD) mice experience autoimmunity before the onset of hyperglycemia, we studied pregnancy outcomes in prediabetic NOD mice using flow cytometry and enzyme-linked immunosorbent assays. Once we determined that adverse events in pregnancy occurred in euglycemic mice, we performed an exploratory study using electronic health records to better understand pregnancy complications in humans with T1D and normal hemoglobin A1c levels.

Setting

University Medical Center.

Patient(s)/animal(s)

Nonobese diabetic mice and electronic health records from Vanderbilt University Medical Center.

Intervention(s)

Nonob

SUBMITTER: McNew KL 

PROVIDER: S-EPMC9850286 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature