OXPHOS promotes apoptotic resistance and cellular persistence in T_H17 cells in the periphery and tumor microenvironment.

ABSTRACT: T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (T_H17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy. T_H17s are long-lived cells that require mitochondrial oxidative phosphorylation (OXPHOS) for effector function in vivo. Considering that T_H17s polarized under standardized culture conditions are predominately glycolytic, little is known about how OXPHOS regulates T_H17 processes, such as their ability to persist and thus contribute to protra

SUBMITTER: Hong HS 

PROVIDER: S-EPMC9853437 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature