Synergistic Effect of Composite Nickel Phosphide Nanoparticles and Carbon Fiber on the Enhancement of Salivary Enzyme-Free Glucose Sensing.

ABSTRACT: An electrospinning method was used for the preparation of an in situ composite based on Ni₂P nanoparticles and carbon fiber (FC). The material was tested for the first time against direct glucose oxidation reaction. The Ni₂P nanoparticles were distributed homogeneously throughout the carbon fibers with a composition determined by thermogravimetric analysis (TGA) of 40 wt% Ni₂P and 60 wt% carbon fiber without impurities in the sample. The electrochemical measurement results indicate that the GCE/FC/Ni₂P in situ sensor exhibits excellent catalytic activity compared to the GCE/Ni₂P and GCE/FC/Ni₂P ex situ electrodes. The GCE/FC/Ni₂P in situ sensor presents a sensitivity of 1050 µAmM^-1cm^-2 in the range of 5-208 µM and a detection limit of 0.25 µM. The sensor was applied for glucose detection in artificial saliva, with a low interference observed from normally coexisting electroactive species. In conclusion, our sensor represents a novel and analytical competitive alternative for the development of non-enzymatic glucose sensors in the future.

SUBMITTER: Brito TP 

PROVIDER: S-EPMC9856003 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature