Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.

ABSTRACT:

Importance

Suicide is a leading cause of death; however, the molecular genetic basis of suicidal thoughts and behaviors (SITB) remains unknown.

Objective

To identify novel, replicable genomic risk loci for SITB.

Design, setting, and participants

This genome-wide association study included 633 778 US military veterans with and without SITB, as identified through electronic health records. GWAS was performed separately by ancestry, controlling for sex, age, and genetic substructure. Cross-ancestry risk loci were identified through meta-analysis. Study enrollment began in 2011 and is ongoing. Data were analyzed from November 2021 to August 2022.

Main outcome and measures

SITB.

Results

A total of 633 778 US military veterans were included in the analysis (57

SUBMITTER: Kimbrel NA 

PROVIDER: S-EPMC9857322 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature