Twins' Macular Pigment Optical Density Assessment and Relation with SCARB1 Gene Polymorphism.

ABSTRACT:

The aim of the study

to assess the influence of genetic and environmental factors using twin studies and evaluate the associations of SCARB1 gene variants (rs11057841) with AMD and MPOD.

Material and methods

a total of 108 healthy twins (56 MZ and 52 DZ twins) were tested in this study. The MPOD was measured using the one-wavelength reflectometry method. Fundus reflectance (Visucam 500, reflectance of a single 460 nm wavelength) was used to measure the MPOD levels, MPOD parameters including max and mean optical density (OD), and area and volume. Real-time polymerase chain reaction was used to detect single nucleotide polymorphisms.

Results

we detected a positive correlation of MPOD in the right and left eyes in MZ twin pairs (r = 0.830 and r = 0.860, respectively) (

SUBMITTER: Kunceviciene E 

PROVIDER: S-EPMC9858834 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature