Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium.

ABSTRACT: Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants significantly associated with all ischemic stroke at array-wide threshold (i.e., p < 4.7 × 10^-7), including two common SNPs in ABO that have previously been associated with stroke. Twelve of the remaining 13 variants were extremely rare in European Caucasians (MAF < 0.1%) and the association

SUBMITTER: Xu H 

PROVIDER: S-EPMC9858999 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature