Graded spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of the mouse spinal cord.

ABSTRACT: The action potential and its all-or-none nature is fundamental to neural communication. Canonically, the action potential is initiated once voltage-activated Na⁺ channels are activated, and their rapid kinetics of activation and inactivation give rise to the action potential's all-or-none nature. Here we demonstrate that cerebrospinal fluid contacting neurons (CSFcNs) surrounding the central canal of the mouse spinal cord employ a different strategy. Rather than using voltage-activated Na⁺ channels to generate binary spikes, CSFcNs use two different types of voltage-activated Ca²⁺ channel, enabling spikes of different amplitude. T-type Ca²⁺ channels generate small amplitude spikes, whereas larger amplitude spikes require high voltage-activated Cd

SUBMITTER: Johnson E 

PROVIDER: S-EPMC9860393 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature