Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors.

ABSTRACT: Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer's disease (AD). In this study, seventeen N-methyl-piperazine chalcones were synthesized, and their inhibitory activities were evaluated against the target enzymes. Compound 2k (3-trifluoromethyl-4-fluorinated derivative) showed the highest selective inhibition against MAO-B with an IC₅₀ of 0.71 μM and selectivity index (SI) of 56.34, followed by 2n (2-fluoro-5-bromophenyl derivative) (IC₅₀ = 1.11 μM, SI = 16.04). Compounds 2k and 2n were reversible competitive MAO-B inhibitors with K_i values of 0.21 and 0.28 μM, respectively. Moreove

SUBMITTER: El-Damasy AK 

PROVIDER: S-EPMC9860728 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature