Mechanism of immune infiltration in synovial tissue of osteoarthritis: a gene expression-based study.

ABSTRACT:

Background

Osteoarthritis is a chronic degenerative joint disease, and increasing evidences suggest that the pathogenic mechanism involves immune system and inflammation.

Aims

The aim of current study was to uncover hub genes linked to immune infiltration in osteoarthritis synovial tissue using comprehensive bioinformatics analysis and experimental confirmation.

Methods

Multiple microarray datasets (GSE55457, GSE55235, GSE12021 and GSE1919) for osteoarthritis in Gene Expression Omnibus database were downloaded for analysis. Differentially expressed genes (DEGs) were identified using Limma package in R software, and immune infiltration was evaluated by CIBERSORT algorithm. Then weighted gene co-expression network analysis (WGCNA) was performed to uncover immune infiltr

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9862811 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature