Determination of Mutational Timing of Colistin-Resistance Genes through Klebsiella pneumoniae Evolution.

ABSTRACT: The emergence and dissemination of carbapenem-resistant Klebsiella pneumoniae (KP), one of the carbapenem-resistant Enterobacteriaceae (CRE), is now an emerging cause of antibiotic-resistant nosocomial infections associated with high rates of morbidity and mortality. Colistin, or polymyxin E, is a last-resort peptide antibiotic used to treat multidrug-resistant (MDR) Gram-negative bacterial infections including KP. Unfortunately, resistance to colistin is rising with increasing use in the clinical setting. Although clinical evidence links certain mutations to colistin resistance (COL-R) in KP, the origination and association of the mutations remain unclear. We hypothesize that the timing of COL-R mutations influences the development and progression of KP resistance to colisti

SUBMITTER: Kuhn JM 

PROVIDER: S-EPMC9862994 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature