Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development.
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ABSTRACT:
SUBMITTER: Schmidt C
PROVIDER: S-EPMC9863218 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development.
Schmidt Christin C Schnierle Barbara S BS
Pathogens (Basel, Switzerland) 20230113 1
The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed. ...[more]
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