Metabolic modelling of the human gut microbiome in type 2 diabetes patients in response to metformin treatment.

ABSTRACT: The human gut microbiome has been associated with several metabolic disorders including type 2 diabetes mellitus. Understanding metabolic changes in the gut microbiome is important to elucidate the role of gut bacteria in regulating host metabolism. Here, we used available metagenomics data from a metformin study, together with genome-scale metabolic modelling of the key bacteria in individual and community-level to investigate the mechanistic role of the gut microbiome in response to metformin. Individual modelling predicted that species that are increased after metformin treatment have higher growth rates in comparison to species that are decreased after metformin treatment. Gut microbial enrichment analysis showed prior to metformin treatment pathways related to the hypoglycemic effect

SUBMITTER: Ezzamouri B 

PROVIDER: S-EPMC9867701 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature