Efficacy and safety of cyclosporine-based regimens for primary immune thrombocytopenia: a systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct a meta-analysis assessing the efficacy and safety of cyclosporine-based combinations for primary immune thrombocytopenia (ITP).

Methods

Randomized controlled clinical trials were collected by systematically searching databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to June 2022. All studies included patients with ITP who received cyclosporine-based regimens. We performed comprehensive analyses of the overall response rate (ORR), complete response (CR) rate, partial response (PR) rate, relapse rate, platelet count, and adverse drug reaction (ADR) rate.

Results

Seven studies (n = 418) were ultimately included. According to a fixed-effects model, cyclosporine-based combinations improv

SUBMITTER: Li X 

PROVIDER: S-EPMC9869211 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature