Removing race from the CKD-EPI equation and its impact on prognosis in a predominantly White European population.

ABSTRACT:

Background

While American nephrology societies recommend using the 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation without a Black race coefficient, it is unknown how this would impact disease distribution, prognosis and kidney failure risk prediction in predominantly White non-US populations.

Methods

We studied 1.6 million Stockholm adults with serum/plasma creatinine measurements between 2007 and 2019. We calculated changes in eGFR and reclassification across KDIGO GFR categories when changing from the 2009 to 2021 CKD-EPI equation; estimated associations between eGFR and the clinical outcomes kidney failure with replacement therapy (KFRT), (cardiovascular) mortality and major adverse cardiovascular even

SUBMITTER: Fu EL 

PROVIDER: S-EPMC9869854 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature