Immunogenicity Characterization of COVID-19 Vaccines: A Systematic Review and Meta-analysis.

ABSTRACT:

Introduction

Immunogenicity has emerged as a challenge in the development of vaccines against coronavirus disease of 2019 (COVID-19). Immunogenicity is a determinant of the efficacy and safety of vaccines. This systematic review and associated meta-analysis summarized and characterized the immunogenicity of COVID-19 vaccines in randomized controlled trials (RCTs).

Methods

Relevant RCTs were systematically sourced from different medical databases in August 2021. The risk ratios and mean differences with 95% confidence intervals were calculated.

Results

Of 2,310 papers, 16 RCTs were eligible for review. These RCTs involved a total of 26,698 participants (15,292 males and 11,231 females). The pooled results showed a significant difference in the geometric mean titer betw

SUBMITTER: Vasconcelos ZS 

PROVIDER: S-EPMC9870285 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature