Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach.

ABSTRACT:

Background

The earliest pathological features of Alzheimer's disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease.

Methods

In total, 144 healthy su

SUBMITTER: Lopez-Cuenca I 

PROVIDER: S-EPMC9872347 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature