Dataset Information

Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data.

ABSTRACT:

Purpose

Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea.

Materials and methods

From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed.

Results

Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range 0-225.5) and median follow-up duration was 88.5 months (range 0-211.6). Overall, 32 patients died, of whom 17, 11, 1, and 3 died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001).

Conclusion

The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.

SUBMITTER: Koh KN

PROVIDER: S-EPMC9873342 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data.

Koh Kyung-Nam KN Han Jung Woo JW Choi Hyoung Soo HS Kang Hyoung Jin HJ Lee Ji Won JW Yoo Keon Hee KH Sung Ki Woong KW Koo Hong Hoe HH Hong Kyung Taek KT Choi Jung Yoon JY Kang Sung Han SH Kim Hyery H Im Ho Joon HJ Hahn Seung Min SM Lyu Chuhl Joo CJ Baek Hee-Jo HJ Kook Hoon H Park Kyung Mi KM Yang Eu Jeen EJ Lim Young Tak YT Kim Seongkoo S Lee Jae Wook JW Chung Nack-Gyun NG Cho Bin B Park Meerim M Park Hyeon Jin HJ Park Byung-Kiu BK Lee Jun Ah JA Park Jun Eun JE Kim Soon Ki SK Kim Ji Yoon JY Kim Hyo Sun HS Ma Youngeun Y Park Kyung Duk KD Park Sang Kyu SK Park Eun Sil ES Shim Ye Jee YJ Yoo Eun Sun ES Ryu Kyung Ha KH Yoo Jae Won JW Lim Yeon Jung YJ Yoon Hoi Soo HS Lee Mee Jeong MJ Lee Jae Min JM Jeon In-Sang IS Jung Hye Lim HL Chueh Hee Won HW Won Seunghyun S

Cancer research and treatment 20220811 1

<h4>Purpose</h4>Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea.<h4>Materials and methods</h4>From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors ...[more]

PMID: 35952715

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Dataset Information

Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data.

Purpose

Materials and methods

Results

Conclusion

Publications

Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data.

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