CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas.

ABSTRACT:

Background

Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of programmed lytic death that has been recently discovered. Caspase 4 (CASP4) plays a key role in pyroptosis. Many studies have shown that pyroptosis is not only related to inflflammation but is also closely related to the occurrence and development of most tumors. This study aimed to prove that CASP4 has a key role in the mechanism of gliomas.

Methods

We used expression data from The Cancer Genome Atlas and the Chinese Glioma Genome At

SUBMITTER: Tian G 

PROVIDER: S-EPMC9874090 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature